Vitamin D Deficiency Associated with Knee Osteoarthritis

Heidari, Heidari, and Hajian-Tilaki investigated the concentration of serum
25-OHD (measurement of vitamin D in the blood) in 148 participants with
knee osteoarthritis versus 150 participants without knee osteoarthritis
(controls). Vitamin D deficiency in this study was defined by having a
serum 25-OHD concentration of less than 20 nanograms/milliliter.

When comparing the mean serum 25-OHD concentrations between all participants with knee osteoarthritis and all controls, no statistically significant differences were found. However, participants under the age of 60 with knee osteoarthritis had a significantly lower mean serum 25-OHD
concentration than controls under the age of 60 (23.8 ng/ml vs. 34.5 ng/ml). The association between vitamin D deficiency and knee
osteoarthritis was statistically significant for participants under the
age of 60; this association was even greater for participants under the
age of 55.

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